Journal: Critical Care

Article Title: Soluble triggering receptor expressed on myeloid cells-1 as a predictive biomarker in sepsis: insights into cut-offs, mortality risk, and treatment guidance—secondary analysis of the Next GeneSiS-Trial

doi: 10.1186/s13054-026-06025-6

Figure Lengend Snippet: Organ dysfunction and sTREM-1 quartiles. Patients were grouped into quartiles according to their SOFA Score at V1 ( A ) and V3 ( B ), their fluid balance at V1 ( C ) and V3 ( D ), their Horowitz index at V1 ( E ) and their thrombocyte count at V1 ( F ). Horizontal line within the box marks the median, boxes depict the IQR, and whiskers indicate the total range. Group comparisons for individual comparisons were performed by two sided Mann–Whitney U-test. *with p-value ≤ 0.05; ** with p-value ≤ 0.01; *** with p-value ≤ 0.001. Abbreviations: sTREM-1: soluble Triggering receptor expressed on myeloid cells-1; SOFA Score: Sequential Organ Failure Assessment

Article Snippet: For predicting need for RRT the best predictive performance was achieved using sTREM-1 plasma concentrations V1 with an AUC of 0.81 (95%CI 0.77–0.88, p < 0.001), outperforming the established functional marker creatinine (AUC 0.73; 95%CI 0.68–0.78, p < 0.001) and the newly described kidney damage marker soluble form of urokinase-type plasminogen activator receptor (suPAR) (AUC 0.68; 95%CI 0.63–0.73, p < 0.001) (Suppl.

Techniques: MANN-WHITNEY

Journal: Critical Care

Article Title: Soluble triggering receptor expressed on myeloid cells-1 as a predictive biomarker in sepsis: insights into cut-offs, mortality risk, and treatment guidance—secondary analysis of the Next GeneSiS-Trial

doi: 10.1186/s13054-026-06025-6

Figure Lengend Snippet: sTREM-1 values in different infection sites. Pulmonal focus presented as cyan bars ( n = 118), abdominal focus as dark green bars ( n = 153), urogenital focus as light green bars ( n = 66) and other focus as purple bars ( n = 163). Horizontal line within the box marks the median, boxes depict the IQR, and whiskers indicate the total range. Group comparisons for V1 and V3 were performed by Kruskal-Wallis test. Group comparisons for individual comparisons were performed by two sided Mann–Whitney U-test. * with p - value ≤ 0.05. Abbreviations: sTREM-1: soluble Triggering receptor expressed on myeloid cells-1

Article Snippet: For predicting need for RRT the best predictive performance was achieved using sTREM-1 plasma concentrations V1 with an AUC of 0.81 (95%CI 0.77–0.88, p < 0.001), outperforming the established functional marker creatinine (AUC 0.73; 95%CI 0.68–0.78, p < 0.001) and the newly described kidney damage marker soluble form of urokinase-type plasminogen activator receptor (suPAR) (AUC 0.68; 95%CI 0.63–0.73, p < 0.001) (Suppl.

Techniques: Infection, MANN-WHITNEY

Journal: Critical Care

Article Title: Soluble triggering receptor expressed on myeloid cells-1 as a predictive biomarker in sepsis: insights into cut-offs, mortality risk, and treatment guidance—secondary analysis of the Next GeneSiS-Trial

doi: 10.1186/s13054-026-06025-6

Figure Lengend Snippet: sTREM-1 values in infections with different pathogens. ( A ) Blood culture negative patients ( n = 351, green bars) had statistically significant lower sTREM-1 plasma concentrations at V1 in comparison to patients with a bacterial or fungal growth in blood culture ( n = 149, red bars). ( B ) sTREM-1 plasma concentrations among more specified different BC results at V1. Gram positive cocci are shown in light purple bars ( n = 64), gram-negative Enterobacteria and Non-fermenters in cyan and dark green bars ( n = 64, n = 4, respectively), fungi in orange bars ( n = 6), multiple in brown bars ( n = 11) and blood culture negative in grey bars ( n = 351). Horizontal line within the box marks the median, boxes depict the IQR, and whiskers indicate the total range. Group comparisons for V1 and V3 were performed by Kruskal-Wallis test. Group comparisons for individual comparisons were performed by two sided Mann–Whitney U-test. *with p - value ≤ 0.05. Abbreviations: sTREM-1: soluble Triggering receptor expressed on myeloid cells-1

Article Snippet: For predicting need for RRT the best predictive performance was achieved using sTREM-1 plasma concentrations V1 with an AUC of 0.81 (95%CI 0.77–0.88, p < 0.001), outperforming the established functional marker creatinine (AUC 0.73; 95%CI 0.68–0.78, p < 0.001) and the newly described kidney damage marker soluble form of urokinase-type plasminogen activator receptor (suPAR) (AUC 0.68; 95%CI 0.63–0.73, p < 0.001) (Suppl.

Techniques: Clinical Proteomics, Comparison, MANN-WHITNEY

Journal: Critical Care

Article Title: Soluble triggering receptor expressed on myeloid cells-1 as a predictive biomarker in sepsis: insights into cut-offs, mortality risk, and treatment guidance—secondary analysis of the Next GeneSiS-Trial

doi: 10.1186/s13054-026-06025-6

Figure Lengend Snippet: Kaplan Meier Curves of sTREM quartiles and cut-offs. A and B. ) Patients grouped according to their sTREM-1 plasma concentration quartiles at V1 and V3, respectively (Q1 presented in dark blue lines, Q2 in light blue, Q3 in orange and Q4 in red); C and D. ) patients are grouped according to the sTREM-1 cut-offs of > 400 and > 532 pg/mL respectively; Survival probability is presented in all subfigures until day 28; the survival probability differs statistically significant in all analysis with p < 0.0001. Abbreviations: sTREM-1: soluble Triggering receptor expressed on myeloid cells-1

Article Snippet: For predicting need for RRT the best predictive performance was achieved using sTREM-1 plasma concentrations V1 with an AUC of 0.81 (95%CI 0.77–0.88, p < 0.001), outperforming the established functional marker creatinine (AUC 0.73; 95%CI 0.68–0.78, p < 0.001) and the newly described kidney damage marker soluble form of urokinase-type plasminogen activator receptor (suPAR) (AUC 0.68; 95%CI 0.63–0.73, p < 0.001) (Suppl.

Techniques: Clinical Proteomics, Concentration Assay